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FDA approval for treatment marks ‘pivotal moment in ALS research’

Published Wed, 12 Mar 2025 23:37:38 GMT

Massachusetts-based Biogen has gotten the green light for a breakthrough ALS treatment that targets a devastating, ultra-rare genetic form of the progressive neurodegenerative disease.The U.S. Food and Drug Administration on Tuesday granted approval of Qalsody for the treatment of ALS in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene. Biogen’s treatment is the first approved treatment to target a genetic cause of ALS.“For more than a decade, Biogen has been steadfast in our commitment to pursuing treatments for ALS, and I want to thank the scientists as well as the entire ALS community who have all worked tirelessly to bring this first-of-its-kind treatment to people with SOD1-ALS,” said Christopher Viehbacher, Biogen’s president and CEO.About 30,000 people in the U.S. have ALS, according to estimates. SOD1-ALS is diagnosed in about 2% of all ALS cases, with about 330 people in the U.S. living with the disease.The FDA approval for the treatment was based on the...

Troy man sentenced 13 years as a second felony offender

Published Wed, 12 Mar 2025 23:37:38 GMT

TROY, N.Y. (NEWS10) -- On Thursday, Bryan Wright, 33, was sentenced to 13 years in prison and 3 years of post-release supervision. Wright is a second felony offender and was found guilty of two counts of Criminal Possession of a Controlled Substance in the Third Degree. Get the latest, news, weather, sports and community events delivered right to your inbox! When he was arrested, Wright was on parole. He was found to be in possession of over a half-ounce of cocaine and almost $3,000 in currency.“Mr. Wright has a history of recidivism. He was convicted of a violent assault in 2014. Less than a year after being released to parole in 2020, he was again arrested and ultimately convicted on new charges for which he served a one-year jail sentence. He was released and placed back under parole supervision in 2021. Within weeks of release, he was arrested on the crimes he was sentenced for today. He was not held in custody after that arrest and, while those charges were pending, he was ch...

Vermonter pleads guilty to attempting to entice a minor

Published Wed, 12 Mar 2025 23:37:38 GMT

ALBANY, N.Y. (NEWS10) -- A West Rutland resident has pled guilty to one count of attempted enticement of a minor. Scarlett Shadows, formerly known as Randy Emillion Goodreau, 32, admitted trying to entice and coerce an individual, who Shadows believed to be an 11-year-old girl, to have sex. Get the latest, news, weather, sports and community events delivered right to your inbox! Shadows admitted to exchanging sexually explicit text messages with the individual and another person they believed was the child's guardian. In January 2022, Shadows traveled from Vermont to Warren County, with an engagement ring, condoms, and gifts for the child, with the intention to have sex with the child.Sahadows faces up to at least ten years and up to life in prison, a fine of up to $250,000, and a term of post-supervised release of at least five years to life. Shadows will be required to register as a sex offender upon release from prison. Sentencing will take place on August 25.

LIVE: Kim Gardner faces second contempt of court hearing

Published Wed, 12 Mar 2025 23:37:38 GMT

ST. LOUIS - For the second time this week, St. Louis Circuit Attorney Kim Gardner faces the prospect of being held in contempt of court.Judge Michael Noble requested that Gardner appear in his courtroom Thursday to "show cause" why she shouldn't be held in contempt. If Gardner fails to appear or show cause, then Noble could levy a fine against the city’s chief prosecutor, put her in jail, or both.This latest contempt of court hearing is the result of an assistant circuit attorney missing an April 10 court date over a shooting case. Our news partners at the St. Louis Post-Dispatch report prosecutor Chris Desilets had another attorney pass a note to Judge Noble, explaining that Desilets had to miss court for a doctor's appointment. New Metro Transit cameras catches suspect in rape attempts Noble asked Desilets to appear in court on April 24 with proof of the doctor's appointment and to reschedule the start of trial. However, Desilets no-showed that hearing as well, prompting Noble t...

Aurora homicide investigators seek public’s help in locating a suspect vehicle and driver

Published Wed, 12 Mar 2025 23:37:38 GMT

Homicide investigators in Aurora are asking for the public’s help in locating a car connected to a shooting in January.Related ArticlesCrime and Public Safety | Rock-throwing suspects turned back to take photo of fatal crash as memento, Jeffco affidavit says Crime and Public Safety | Denver police seek tips from the public in parking lot homicide investigation Crime and Public Safety | 3 suspects arrested in rock-throwing spree that killed Alexa Bartell in west metro Denver Crime and Public Safety | Victim in Jefferson County rock-hurling attacks mourns the loss of life in crime spree Crime and Public Safety | Police ID victims of double murder at American Elm restaurant in northwest Denver Aurora police are looking for a dark gray car, believed to be a Mercedes-Benz C-Class, linked to an early-morning Jan. 30 shooting in the 1500 block of Dallas Street, according to a Metro Denver Crime Stoppers t...

Avalanche vs. Kraken: Three keys to Game 6 survival for Colorado

Published Wed, 12 Mar 2025 23:37:38 GMT

Cale Makar is 3-3 in playoff elimination games in his career. Nathan MacKinnon is 4-5, including two Game 7 overtime losses.The Avs never once had their backs to the wall during the 2022 Stanley Cup Playoffs. Now their generational core faces an uphill climb. Trailing 3-2 to the Kraken, the Avalanche play Game 6 on Friday (7 p.m. MT, TNT) back at Seattle’s Climate Pledge Arena. Here are three keys to forcing a Game 7.1. Drown it out, Cale. Makar will be greeted with enthusiastic loathing in his return from a one-game suspension. The Avs haven’t lost a road game in regulation since March 4. But their best player never faced a deafening boo chorus during that run. Makar claimed that “I don’t really hear it that much” when he’s on the ice. If that’s what works for him, so be it. Some embrace the villainy; others ignore it. Either way, Makar needs to be sharp in a hostile elimination atmosphere.2. Georgiev v. Grubauer is misleading. Starting in his fi...

Are there enough free preschool seats for Colorado 4-year-olds? It depends.

Published Wed, 12 Mar 2025 23:37:38 GMT

Since Colorado leaders began planning a major expansion of state-funded preschool more than two years ago, parents and advocates have wondered: Will there be enough seats for everybody who wants one?The answer: It depends.On paper, there are plenty of seats. State officials expect only about half of Colorado’s 4-year-olds — around 31,000 children — to participate in the first year. Meanwhile, a Chalkbeat analysis found more than 56,000 preschool seats available for next fall.“Right now, it’s looking really good,” said Dawn Odean, the state’s universal preschool director.But things get stickier at the county level. Some parts of the state are awash in preschool seats and others don’t have nearly enough. Some families may also struggle to find preschools with the schedules and programming they want.“The physical number of slots versus what parents actually need doesn’t necessarily align,” said Kelly Esch, who’s both the parent of a preschooler and executive director of an organi...

In-N-Out Burger opens Denver location on Friday

Published Wed, 12 Mar 2025 23:37:38 GMT

The Mile High City gets its first In-N-Out Burger on Friday, April 28, when the California-based fast-food chain opens its newest location in the metro area.Get fries with that shake at 4597 N. Central Park Blvd. in the Central Park neighborhood (formerly Stapleton), just off Interstate 70. The restaurant joins previous In-N-Out locations in Aurora, Lakewood, Lone Tree and Thornton. There are also two locations in Colorado Springs.Two other locations may also be in the works, in Loveland and at Tower Road and 56th Avenue in Denver.“As with all locations, fresh ingredients will be supplied to the store from In-N-Out,” the company said in a statement. “Hamburger patties are made from 100% American beef and whole chucks are boned and ground by In-N-Out’s own butchers. All patties are produced and delivered fresh throughout the week to the stores and are never frozen. French fries are made from fresh, whole potatoes and are hand diced.”In-N-Out said it will...

LAUSD Superintendent responds to tragic crosswalk accident that killed young mother

Published Wed, 12 Mar 2025 23:37:38 GMT

"It's heartbreaking, it's unacceptable and it's preventable."Los Angeles Unified School District Superintendent Alberto Carvalho responded Thursday to this week’s tragic accident that took the life of a young mother who was walking her six-year-old daughter to school. Ghadah Abduljabbar, 33, and her daughter were struck by the driver of a pickup truck as they walked in a crosswalk near Hancock Park School Tuesday morning. The 6-year-old girl was listed in critical condition.Officials say the driver who hit them apparently suffered a medical emergency.Carvalho said he's pushing for more measures to make sure students get to the classroom safely.Currently, there are only 500 crossing guards in the community and 200 of those positions are vacant, Carvalho said on KTLA 5 Morning News. He says even if all positions were filled, it's still an insufficient amount for the 1400 education centers around Los Angeles. The city and county are in charge of filling crossing guard positions. Just ...

Listen to Beyonce's hits with a classical twist amid candlelight in L.A.

Published Wed, 12 Mar 2025 23:37:38 GMT

While the Beyhive awaits Beyonce's return to the concert stage, an "Irreplaceable" experience to honor the singer is coming to Los Angeles. Beyonce to add 2nd Inglewood show to Renaissance World Tour Candlelight: A Tribute to Beyonce is a concert series put on by Candlelight Concerts by Fever. Queen Bey's hits are played live by local musicians by candlelight.Fans will hear hits like "Single Ladies, "Best Thing I Never Had," "If I Were a Boy," Survivor," "Cuff It" and "Crazy in Love" with a classical twist at one of L.A.'s famous landmarks. "Candlelight was initially conceived as a classical music series with concerts featuring works from the greatest composers, such as Vivaldi, Mozart, and Chopin. Now, the ever-growing list of programs includes a wide variety of themes and genres, including tributes to contemporary artists," the website said. "This multi-sensory experience has also evolved to feature different elements, such as ballet dancers or aerial performers, as well as oth...